In a MASLD population, a lower ceruloplasmin level is significantly associated with younger age and a riskier atherogenic profile (lower HDL c), and may be explained by the protein's antioxidant properties. This justifies not using ceruloplasmin levels solely to exclude Wilson's disease, since its low level probably confers an increased cardiovascular risk in these patients. This needs to be assessed in prospective follow up studies.
Gason Rémi, & et al. (2025). A low level of ceruloplasmin is associated with an atherogenic profile and the presence of MASLD at a younger age. Belgian gastro week, Liège. https://hdl.handle.net/2078.5/241551