Multivariate evaluation of the functional recovery obtained by the overexpression of utrophin in skeletal muscles of the mdx mouse.
(2002) Neuromuscular Disorders — Vol. 12 Suppl 1, p. S90-4 (2002)
Files
9227.pdf
Restricted Access - Adobe PDF
- 139.08 KB
Details
- Authors
- Abstract
- This paper summarizes the various aspects of functional recovery obtained in dystrophin-deficient muscles of the mdx mice where utrophin was overexpressed. This includes preliminary results on tetracycline-controlled expression of utrophin. It is shown that overexpression of utrophin leads to major functional improvements and that full-length utrophin is more efficient than truncated utrophin, missing a part of the central rod-segment. A generalized way of presenting improvements obtained by any treatment in the form of a 'recovery score' is emphasized. The quantitative aspect of the replacement of dystrophin by utrophin is discussed.
- Affiliations
Citations
Gillis, J.-M. (2002). Multivariate evaluation of the functional recovery obtained by the overexpression of utrophin in skeletal muscles of the mdx mouse. Neuromuscular Disorders, 12 Suppl 1, S90-4. https://doi.org/10.1016/S0960-8966(02)00088-3 (Original work published 2002)