Role of the sarco-endoplasmic reticulum Ca2+-ATPase SERCA3 in Ca2+ signaling in mouse Beta-cells
(2001) 37th Annual Meeting of the EASD — Location: (United Kingdom) Glasgow (9.September.2001)
Files
2001_Arredouani_EASD_Abstract_475.pdf
Open Access - Adobe PDF
- 1.97 MB
Details
- Authors
- Abstract
- Pancreatic islets express both the high Ca" -affinity SERCA2b and the low Ca"-affinity SERCA3. Dysregulation of the SERCA3 activity has been associated with type 2 diabetes in mice and humans. Wild type (+f+) and SERCA3 KO (-f.) mice were used to evaluate the role of SERCA3 in J3-cell [Ca'+], regulation and insulin secretion, and to estimate its contribution to glucose homeostasis [...]
- Affiliations
Citations
Arredouani, A., Pertusa, J., Rolland, J.-F., Liu, L. H., Shull, G. E., Henquin, J.-C., & Gilon, P. (2001). Role of the sarco-endoplasmic reticulum Ca2+-ATPase SERCA3 in Ca2+ signaling in mouse Beta-cells. Diabetologia : clinical and experimental diabetes and metabolism, 44(Suppl 1), A125. https://hdl.handle.net/2078.5/119026 (Original work published 2001)