Livers of genetically obese (fa/fa) rats, starved for 24 h, contained more fructose 2,6-bisphosphate, glucose 6-phosphate, fructose 6-phosphate and glycogen, and more pyruvate kinase and phosphofructokinase 2 activities, than livers of control lean rats. These changes may be explained in terms of cyclic AMP concentration, which was decreased in livers of obese starved rats.
Hue, L., van de Werve, G., & Jeanrenaud, B. (1983). Fructose 2,6-bisphosphate in livers of genetically obese rats. The Biochemical journal, 214(3), 1019-1022. https://hdl.handle.net/2078.5/133397 (Original work published 1983)