N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, a Potent Melatonin Analog

Tinant, Bernard;Declercq, Jean-Paul;Poupaert, Jacques;Yous, S.;Lesieur, D.
(1994) Acta Crystallographica. Section C: Crystal Structure Communications — Vol. 50, p. 907-910 (1994)

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  • Tinant, BernardUCLouvain
    Author
  • Declercq, Jean-PaulUCLouvain
    Author
  • Poupaert, JacquesUCLouvain
    Author
  • Yous, S.
    Author
  • Lesieur, D.
    Author
Abstract
The four crystallographically independent molecules present in the unit cell of N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, C15H17NO2, are very similar; the naphthalene ring is planar, the methoxy substituent is staggered and the side chain is oriented so that the amide and aromatic groups are approximately parallel. This conformation of the longer side chain is different from the fully extended conformation observed in the neurohormone melatonin.
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Tinant, B., Declercq, J.-P., Poupaert, J., Yous, S., & Lesieur, D. (1994). N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, a Potent Melatonin Analog. Acta Crystallographica. Section C: Crystal Structure Communications, 50, 907-910. https://doi.org/10.1107/S0108270193012922 (Original work published 1994)