Insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin-like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats.

Kok, N N;Morgan, L M;Williams, C M;Roberfroid, Marcel;Delzenne, Nathalie;et.al.
(1998) The Journal of Nutrition — Vol. 128, n° 7, p. 1099-1103 (1998)

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Authors
  • Kok, N N
    Author
  • Morgan, L M
    Author
  • Williams, C M
    Author
  • Roberfroid, MarcelUCLouvain
    Author
  • Thissen, Jean-Paulorcid-logoUCLouvain
    Author
  • Delzenne, NathalieUCLouvain
    Author
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Abstract
The addition of oligofructose as a dietary fiber decreases the serum concentration and the hepatic release of VLDL-triglycerides in rats. Because glucose, insulin, insulin-like growth factor I (IGF-I) and gut peptides [i.e., glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)]) are factors involved in the metabolic response to nutrients, this paper analyzes their putative role in the hypolipidemic effect of oligofructose. Male Wistar rats were fed a nonpurified diet with or without 10% oligofructose for 30 d. Glucose, insulin, IGF-I and GIP concentrations were measured in the serum of rats after eating. GIP and GLP-1 contents were also assayed in small intestine and cecal extracts, respectively. A glucose tolerance test was performed in food-deprived rats. Serum insulin level was significantly lower in oligofructose-fed rats both after eating and in the glucose tolerance test, whereas glycemia was lower only in the postprandial state. IGF-I serum level did not differ between groups. GIP concentration was significantly higher in the serum of oligofructose-fed rats. The GLP-1 cecal pool was also significantly higher. In this study, we have shown that cecal proliferation induced by oligofructose leads to an increase in GLP-1 concentration. This latter incretin could be involved in the maintenance of glycemia despite a lower insulinemia in the glucose tolerance test in oligofructose-fed rats. We discuss also the role of hormonal changes in the antilipogenic effect of oligofructose.
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Kok, N. N., Morgan, L. M., Williams, C. M., Roberfroid, M., Thissen, J.-P., & Delzenne, N. (1998). Insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin-like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats. The Journal of Nutrition, 128(7), 1099-1103. https://hdl.handle.net/2078.5/60316 (Original work published 1998)