Transcriptional activation of HMGI-C in three pulmonary hamartomas each with a der(14) t(12;14) as the sole cytogenetic abnormality
(1996) Cancer Letters — Vol. 102, n° 1-2, p. 17-21 (1996)
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- Aberrations involving the chromosomal region 12q14-15 are non-random cytogenetic abnormalities in many benign tumors, e.g. pulmonary chondroid hamartomas (PCH). Recently, we identified rearrangements of the HMGI-C gene within the third or fourth intron as the molecular mechanism underlying most of these chromosomal aberrations. Herein we report our FISH and RACE studies on three PCHs each showing a rare variant type of the translocation t(12;14)(q14-15;q24) with presence of two normal chromosomes 12 and a der(14) but missing the der(12). The results revealed that in all three cases the breakpoint is located 5' to HMGI-C, suggesting that besides intragenic rearrangements also transcriptional activation of the gene can initiate tumor growth.
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Wanschura, S., Kazmierczak, B., Pohnke, Y., MeyerBolte, K., Bartnitzke, S., VandeVen, W., & Bullerdiek, J. (1996). Transcriptional activation of HMGI-C in three pulmonary hamartomas each with a der(14) t(12;14) as the sole cytogenetic abnormality. Cancer Letters, 102(1-2), 17-21. https://doi.org/10.1016/0304-3835(96)04144-4 (Original work published 1996)