alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway.
(2006) Science — Vol. 311, n° 5767, p. 1609-1612 (2006)
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- Abstract
- During development, cells monitor and adjust their rates of accumulation to produce organs of predetermined size. We show here that central nervous system-specific deletion of the essential adherens junction gene, alphaE-catenin, causes abnormal activation of the hedgehog pathway, resulting in shortening of the cell cycle, decreased apoptosis, and cortical hyperplasia. We propose that alphaE-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex.
- Affiliations
Fred Hutchinson Cancer Research Center Division of Human Biology
Citations
Lien, W.-H., Klezovitch, O., Fernandez, T. E., Delrow, J., & Vasioukhin, V. (2006). alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science, 311(5767), 1609-1612. https://doi.org/10.1126/science.1121449 (Original work published 2006)