Role of TRPC1 in the brain in physiological and pathological conditions
(2018)
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- Abstract
- TRPC1 is a non-selective ion channel belonging to the TRPs superfamily (transient receptor potential). It is expressed in most tissues and especially in the brain. Its location, its function and its activation mechanism are still unknown. In this thesis, we study the expression and the role of TRPC1 in the mammalian brain and particularly in two cell types: astrocytes and neurons. We have highlighted that TRPC1 in neurons, could be involved in spatial memory and working memory. Its activation in glutamatergic synapses of the hippocampus, depends on the metabotropic glutamate receptor mGlur5 and contributes to the maintenance of the phenomenon of long-term potentiation or long-term depression. In addition, in astrocytic-type glioblastoma cells, TRPC1 could be activated by the sphingosine-1-phosphate lipid produced by PDGF receptor stimulation. TRPC1, thus activated, would allow the chemotactic migration of these cells. Our work provides a better understanding of the physiological importance of TRPC1 in several mammalian brain cell sub-types and contributes to the understanding of its role in some pathological conditions.
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Lepannetier, S. (2018). Role of TRPC1 in the brain in physiological and pathological conditions. https://hdl.handle.net/2078.5/48070