Antimitotic and cytotoxic activities of guattegaumerine, a bisbenzylisoquinoline alkaloid
(1987) Planta Medica : natural products and medicinal plant research — Vol. 53, n° 1, p. 116-117 (1987)
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- Guattegaumerine was isolated from the bark of Guatteria gaumeri ( cf Dehaussy, Tits and Angenot, Planta Med. (1983) 49, 25-27) , a medicinal plant called Yumel in Yucatan (South Mexico).Guattegaumerine exerts a good activity at 5 micrograms/ml on B16 melanoma which is a relatively resistant tumor. It is less active against 2002 cells that are normal human cells.
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Quetin-Leclercq, J., De Pauw-Gillet, M.-C., Bassleer, R., & Angenot, L. (1987). Antimitotic and cytotoxic activities of guattegaumerine, a bisbenzylisoquinoline alkaloid. Planta Medica : natural products and medicinal plant research, 53(1), 116-117. https://doi.org/10.1055/s-2006-962646 (Original work published 1987)