Combined effect of PLGA and curcumin on wound healing activity
(2013) Journal of Controlled Release — Vol. 171, n° 2, p. 208-215 (2013)
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- Abstract
- Wound healing is a complex process involving many interdependent and overlapping sequences of physiological actions. The application of exogenous lactate released from poly (lactic-co-glycolic acid) (PLGA) polymer accelerated angiogenesis and wound healing processes. Curcumin is a well-known topical wound healing agent for both normal and diabetic-impaired wounds. Hence, we hypothesized that the PLGA nanoparticles encapsulating curcumin could much potentially accelerate the wound healing. In a full thickness excisional wound healing mouse model, PLGA-curcumin nanoparticles showed a twofold higher wound healing activity compared to that of PLGA or curcumin. Histology and RT-PCR studies confirmed that PLGA-curcumin nanoparticles exhibited higher re-epithelialization, granulation tissue formation and anti-inflammatory potential. PLGA nanoparticles offered various benefits for the encapsulated curcumin like protection from light degradation, enhanced water solubility and showed a sustained release of curcumin over a period of 8 days. In conclusion, we demonstrated the additive effect of lactic acid from PLGA and encapsulated curcumin for the active healing of wounds.
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Chereddy, K. K., Coco, R., Memvanga Bondo, P., Ucakar, B., des Rieux, A., Vandermeulen, G., & Préat, V. (2013). Combined effect of PLGA and curcumin on wound healing activity. Journal of Controlled Release, 171(2), 208-215. https://doi.org/10.1016/j.jconrel.2013.07.015 (Original work published 2013)