Sequential Induction Chemotherapy With Vincristine, Daunorubicin, Cyclophosphamide, and Prednisone in Adult Acute Lymphoblastic-leukemia
(1995) Annals of Hematology — Vol. 70, n° 2, p. 65-69 (1995)
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- Sequential chemotherapy with vincristine, daunorubicin, cyclophosphamide, and prednisone doses was administered to 57 adult patients with acute lymphoblastic leukemia (ALL). Complete remission (CR) was achieved in 51 (89%, 95% confidence intervals, [CI] 78-96%). Among patients achieving CR, 62% were in CR after one sequence of chemotherapy, 23% after two sequences, and 5% after three sequences. Six patients (11%) had resistant disease. All patients experienced profound myelosuppression. Median time to recovery of neutrophils >0.5 x 10(9)/l was 22 days (range: 5-89 days), and of platelets >100 x 10(9)/l 21 days (range: 0-45 days). Nonhematologic WHO grade 3 or more side effects consisted predominantly of hyperbilirubinemia (7%), mucositis (5%), nausea and vomiting (2%), and cutaneous toxicity (1%). Severe infectious complications occurred in only 14% of cases. One patient (2%, 95% CI 0-9%) died of therapy-related toxicity while in early CR. We concluded that sequential use of prednisone seemed at least as effective as continuous administration at the expense of a few adverse side effects.
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Thomas, X., Danaila, C., Bach, QK., Dufour, P., Christian, B., Corront, B., Bosly, A., Bastion, Y., Gratecos, N., Leblay, R., Sebban, C., Archimbaud, E., & Fiere, D. (1995). Sequential Induction Chemotherapy With Vincristine, Daunorubicin, Cyclophosphamide, and Prednisone in Adult Acute Lymphoblastic-leukemia. Annals of Hematology, 70(2), 65-69. https://doi.org/10.1007/BF01834381 (Original work published 1995)