Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
(2007) Nature Genetics — Vol. 39, n° 5, p. 593-595 (2007)
Files
37619.pdf
Restricted Access - Adobe PDF
- 2.64 MB
Details
- Authors
- Abstract
- We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
- Affiliations
Citations
Lahortiga, I., De Keersmaecker, K., Van Vlierberghe, P., Graux, C., Cauwelier, B., Lambert, F., Mentens, N., Beverloo, H. B., Pieters, R., Speleman, F., Odero, M. D., Bauters, M., Froyen, G., Marynen, P., Vandenberghe, P., Wlodarska, I., Meijerink, J. P. P., & Cools, J. (2007). Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nature Genetics, 39(5), 593-595. https://doi.org/10.1038/ng2025 (Original work published 2007)