Clinical, Histologic and Quantitative Angiographic Predictors of Restenosis After Directional Coronary Atherectomy - a Multivariate-analysis of the Renarrowing Process and Late Outcome

Umans, Victor A. W. M.;Robert, Annie;Foley, David;Wijns, William;Serruys, Patrick W.;et.al.
(1994) Journal of the american college of cardiology : JACC — Vol. 23, n° 1, p. 49-58 (1994)

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  • Umans, Victor A. W. M.
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  • Robert, AnnieUCLouvain
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  • Foley, David
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  • Wijns, William
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  • Serruys, Patrick W.
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Abstract
(en) OBJECTIVES: To characterize predictors of restenosis after successful directional atherectomy, we reviewed the clinical, angiographic and procedural data obtained during 132 consecutive procedures. METHODS: Clinical and angiographic follow-up data were obtained in a prospectively collected and consecutive series of 125 patients who underwent 132 atherectomy procedures for de novo (89%) or restenotic (11%) lesions in native coronary arteries. Restenosis was assessed clinically and by quantitative coronary angiography. A dual approach to data analysis was taken to gain insight into factors affecting the clinical outcome and vessel wall healing response. Therefore, multivariate analysis was performed to 1) determine the correlates of residual lumen diameter at follow-up (angiographic outcome), and 2) characterize the determinants of the late lumen loss (renarrowing process). RESULTS: Clinical and angiographic follow-up data after successful atherectomy were obtained in 100% and 95%, respectively. Atherectomy achieved an acute lumen gain of 1.28 +/- 0.48 mm (mean +/- SD), resulting in a minimal lumen diameter of 2.44 +/- 0.47 mm. At follow-up, the minimal lumen diameter decreased to 1.78 +/- 0.64 mm. The angiographic restenosis rate was 28% if the traditional 50% stenosis cutoff criterion was applied. Larger vessel size and postatherectomy minimal lumen diameter and right coronary or left circumflex artery lesions were independent predictors of a larger minimal lumen diameter (angiographic outcome). Lumen loss during follow-up (renarrowing process) was independently predicted by relative lumen gain and preprocedural minimal lumen diameter. CONCLUSIONS: In analyzing the long-term results of new interventional techniques such as directional atherectomy, the late lumen loss during follow-up (renarrowing process), which is characterized by the vessel wall healing response after an intervention, should be considered together with the residual lumen diameter at follow-up (clinical outcome). It is clear that whereas improved clinical outcome is associated with larger vessel size and postprocedural lumen diameter and non-left anterior descending artery location, greater relative gain at intervention is predictive of more extensive lumen renarrowing.
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Umans, V. A. W. M., Robert, A., Foley, D., Wijns, W., Haine, E., Defeyter, P. J., & Serruys, P. W. (1994). Clinical, Histologic and Quantitative Angiographic Predictors of Restenosis After Directional Coronary Atherectomy - a Multivariate-analysis of the Renarrowing Process and Late Outcome. Journal of the american college of cardiology : JACC, 23(1), 49-58. https://doi.org/10.1016/0735-1097(94)90501-0 (Original work published 1994)