Increased susceptibility of Pseudomonas aeruginosa to macrolides and ketolides in eukaryotic cell culture media and biological fluids due to decreased expression of oprM and increased outer-membrane permeability.

Buyck, Julien M;Plésiat, Patrick;Traore, H;Vanderbist, F;Van Bambeke, Françoise;et.al.
(2012) Clinical infectious diseases : an official publication of the Infectious Diseases Society of America — Vol. 55, n° 4, p. 534-542 (2012)

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Authors
  • Buyck, Julien M
    Author
  • Plésiat, Patrick
    Author
  • Traore, H
    Author
  • Vanderbist, F
    Author
  • Tulkens, Paul M.UCLouvain
    Author
  • Van Bambeke, Françoiseorcid-logo
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Abstract
Macrolides show antimicrobial activity against P. aeruginosa in eukaryotic media through increased uptake and reduced efflux. These data may help explain the clinical efficacy of macrolides against pseudomonal infections.
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Buyck, J. M., Plésiat, P., Traore, H., Vanderbist, F., Tulkens, P. M., & Van Bambeke, F. (2012). Increased susceptibility of Pseudomonas aeruginosa to macrolides and ketolides in eukaryotic cell culture media and biological fluids due to decreased expression of oprM and increased outer-membrane permeability. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 55(4), 534-542. https://doi.org/10.1093/cid/cis473 (Original work published 2012)