Transgenic Mice for Real Time Visualization of cGMP in Intact Adult Cardiomyocytes.

Götz, Konrad;Sprenger, Julia;Perera, Ruwan K;Steinbrecher, Julia H;Nikolaev, Viacheslav O;et.al.
(2014) Circulation Research — (2014)

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Authors
  • Götz, Konrad
    Author
  • Sprenger, Julia
    Author
  • Perera, Ruwan K
    Author
  • Steinbrecher, Julia H
    Author
  • Balligand, Jean-LucUCLouvain
    Author
  • Nikolaev, Viacheslav O
    Author
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Abstract
cGMP is an important second messenger which regulates cardiac contractility and protects the heart from hypertrophy. However, due to the lack of real time imaging techniques, specific subcellular mechanisms and spatio-temporal dynamics of cGMP in adult cardiomyocytes are not well understood.
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Götz, K., Sprenger, J., Perera, R. K., Steinbrecher, J. H., Lehnart, S. E., Kuhn, M., Gorelik, J., Balligand, J.-L., & Nikolaev, V. O. (2014). Transgenic Mice for Real Time Visualization of cGMP in Intact Adult Cardiomyocytes. Circulation Research. Published. https://doi.org/10.1161/CIRCRESAHA.114.302437 (Original work published 2014)