Novel approaches to investigate central sensitization : from experimental models to clinical perspectives
(2025)
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- Abstract
- Chronic pain is a debilitating condition affecting millions worldwide. It is thought to be associated with central sensitization, a phenomenon where the central nervous system amplifies pain signals, leading to increased sensitivity and prolonged pain perception. Through experimental electrical skin stimulation, this thesis investigates innovative approaches to reliably induce central sensitization in humans, evaluates potential biomarkers for its assessment, and examines psychological factors that influence its modulation. From a clinical perspective, this research assesses how these findings translate to predicting persistent post-surgical pain in patients, offering promising avenues for targeted interventions.
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Citations
Gousset, S. (2025). Novel approaches to investigate central sensitization : from experimental models to clinical perspectives. https://hdl.handle.net/2078.5/243045