Changes in imprinted gene dosage in the placenta may compromise the prenatal control of nutritional resources. Indeed monoallelic behaviour and sensitivity to changes in regional epigenetic state render imprinted genes both vulnerable and adaptable.
Affiliations
UCLouvainSST/ISV - Institut des sciences de la vie
Gallou-Kabani, C., Gabory, A., Tost, J., Karimi, M., Mayeur, S., Lesage, J., Boudadi, E., Gross, M.-S., Taurelle, J., Vigé, A., Breton, C., Reusens, B., Remacle, C., Vieau, D., Ekström, T. J., Jais, J.-P., & Junien, C. (2010). Sex- and diet-specific changes of imprinted gene expression and DNA methylation in mouse placenta under a high-fat diet. PLoS One, 5(12), e14398. https://doi.org/10.1371/journal.pone.0014398 (Original work published 2010)