Effets d'un entrainement en endurance sur les caractéristiques musculaires des patients drépanocytaires homozygotes
(2019)
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- Abstract
- Sickle cell disease is a genetic hemoglobinopathy resulting in chronic and severe hemolytic anemia and iterative vaso-occlusive crisis. This pathology is also accompanied by exercise intolerance and alterations in muscle function and tissue. Recently, we demonstrated, through a randomized controlled study, the safety and functional benefits of a moderate-intensity endurance exercise training program in sickle cell disease patients. The aim of this thesis was to evaluate the effects of this training program on the muscle characteristics of forty homozygous sickle cell disease patients. The analysis of muscle biopsies reported tissue adaptations in trained patients, illustrated by an increase in the surface area of myocytes, an improvement in their oxidative capacity, an increase in the number of microvessels without modification of their tortuosity, suggesting a better muscle oxygenation. Thus, this training provided functional benefits, but also reduced muscle tissue dysfunctions.
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Citations
Merlet, A. (2019). Effets d’un entrainement en endurance sur les caractéristiques musculaires des patients drépanocytaires homozygotes. https://hdl.handle.net/2078.5/52777