Rapid improvement of bone metabolism after infliximab treatment in Crohn's disease
(2004) Alimentary Pharmacology and Therapeutics — Vol. 20, n° 6, p. 607-614 (2004)
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- Background: Crohn's disease is associated with low bone mineral density and altered bone metabolism. Aim: To assess the evolution of bone metabolism in Crohn's disease patients treated with infliximab. Methods: We studied 71 Crohn's disease patients treated for the first time with infliximab for refractory Crohn's disease. Biochemical markers of bone formation (type-I procollagen N-terminal propeptide, bone-specific alkaline phosphatase, osteocalcin) and of bone resorption (C-telopeptide of type-I collagen) were measured in the serum before and 8 weeks after infliximab therapy and compared with values in a matched healthy control group. Results: Eight weeks after treatment with infliximab, a normalization of bone markers was observed with a median increase in formation markers of 14-51% according to marker and a lower but significant decrease in resorption marker (median 11%). A clinically relevant increase in bone formation markers was present in 30-61% of patients according to the marker. A clinically relevant decrease in C-telopeptide of type-I collagen was present in 38% of patients. No association was found with any tested demographic or clinical parameter. Conclusion: Infliximab therapy in Crohn's disease may rapidly influence bone metabolism by acting either on bone formation or bone resorption. This improvement seems to be independent of clinical response to infliximab.
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Franchimont, N., Putzeys, V., Collette, J., Vermeire, S., Rutgeerts, P., De Vos, M., Van Gossum, A., Franchimont, D., Fiasse, R., Pelckmans, P., Malaise, M., Belaiche, J., & Louis, E. (2004). Rapid improvement of bone metabolism after infliximab treatment in Crohn’s disease. Alimentary Pharmacology and Therapeutics, 20(6), 607-614. https://doi.org/10.1111/j.1365-2036.2004.02152.x (Original work published 2004)