Isolation and mass spectrometric identification of two metabolites of FK 506 from rat liver microsomal incubation media.

Lhoëst, G;Maton, Nicole;Verbeeck, Roger-K.
(1992) Pharmaceutica Acta Helvetiae — Vol. 67, n° 9-10, p. 270-274 (1992)

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  • Lhoëst, G
    Author
  • Maton, NicoleUCLouvain
    Author
  • Verbeeck, Roger-K.UCLouvain
    Author
Abstract
A transient epoxide in equilibrium with its possible isomeric forms, most probably induced easily by neighboring-group assistance of a hydroxy group, and a dihydrodiol formed under the influence of the hydrase enzymic activity and/or by simple hydrolysis were isolated by HPLC and identified by FAB/MS from rat liver microsomal incubation media.
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Lhoëst, G., Maton, N., & Verbeeck, R.-K. (1992). Isolation and mass spectrometric identification of two metabolites of FK 506 from rat liver microsomal incubation media. Pharmaceutica Acta Helvetiae, 67(9-10), 270-274. https://hdl.handle.net/2078.5/86264 (Original work published 1992)