Further characterization of cardiodigin, Na+, K+-ATPase inhibitor extracted from mammalian tissues.
(1985) FEBS Letters — Vol. 184, n° 1, p. 150-154 (1985)
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- Abstract
- This study was undertaken to characterize endogenous digitalis-like activity in water extract from mammalian tissues. Prepurified samples obtained from guinea-pig heart were analysed by reverse-phase HPLC using an acetonitrile gradient. The eluent was assayed for its activity as inhibitor of human heart Na+, K+-ATPase and digoxin-like immunoreactivity. Both activities were recovered in the same fraction after two successive chromatographic steps. These results provide further evidence for the presence of an endogenous digitalis-like factor, cardiodigin, in mammalian heart.
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Fagoo, M., & Godfraind, T. (1985). Further characterization of cardiodigin, Na+, K+-ATPase inhibitor extracted from mammalian tissues. FEBS Letters, 184(1), 150-154. https://doi.org/10.1016/0014-5793(85)80672-4 (Original work published 1985)