Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone.

Swerdlow, Anthony J;Cooke, Rosie;Albertsson-Wikland, Kerstin;Borgström, Birgit;Carel, Jean-Claude;et.al.
(2015) Hormone Research in Paediatrics : from developmental endocrinology to clinical research — Vol. 84, n° 3, p. 172-183 (2015)

Files

2015_Swerdlow_Horm_Res_Paediatr.pdf
  • Open Access
  • Adobe PDF
  • 135.78 KB
Download

Details

Authors
  • Swerdlow, Anthony J
    Author
  • Cooke, Rosie
    Author
  • Albertsson-Wikland, Kerstin
    Author
  • Borgström, Birgit
    Author
  • Maes, MarcUCLouvain
    Author
  • Carel, Jean-Claude
    Author
Show more
Abstract
The long-term safety of growth hormone treatment is uncertain. Raised risks of death and certain cancers have been reported inconsistently, based on limited data or short-term follow-up by pharmaceutical companies. The SAGhE (Safety and Appropriateness of Growth Hormone Treatments in Europe) study assembled cohorts of patients treated in childhood with recombinant human growth hormone (r-hGH) in 8 European countries since the first use of this treatment in 1984 and followed them for cause-specific mortality and cancer incidence. Expected rates were obtained from national and local general population data. The cohort consisted of 24,232 patients, most commonly treated for isolated growth failure (53%), Turner syndrome (13%) and growth hormone deficiency linked to neoplasia (12%). This paper describes in detail the study design, methods and data collection and discusses the strengths, biases and weaknesses consequent on this. The SAGhE cohort is the largest and longest follow-up cohort study of growth hormone-treated patients with follow-up and analysis independent of industry. It forms a major resource for investigating cancer and mortality risks in r-hGH patients. The interpretation of SAGhE results, however, will need to take account of the methods of cohort assembly and follow-up in each country.
Affiliations

Citations

  • APA
  • Chicago
  • FWB

Swerdlow, A. J., Cooke, R., Albertsson-Wikland, K., Borgström, B., Butler, G., Cianfarani, S., Clayton, P., Coste, J., Deodati, A., Ecosse, E., Gausche, R., Giacomozzi, C., Kiess, W., Hokken-Koelega, A. C. S., Kuehni, C. E., Landier, F., Maes, M., Mullis, P.-E., Pfaffle, R., et al. (2015). Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone. Hormone Research in Paediatrics : from developmental endocrinology to clinical research, 84(3), 172-183. https://doi.org/10.1159/000435856 (Original work published 2015)