Effectiveness of the South African expanded program of immunization against hepatitis B in children infected with human immunodeficiency virus-1 living in a resource-limited setting of Kwazulu-Natal

Beghin, Jean-Christophe;Ruelle, Jean;Sokal, Etienne;Bachy, Antoine;Van der Linden, Dimitri;et.al.
(2017) Journal of Medical Virology — Vol. 89, n° 1, p. 182-185 (2017)

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Abstract
Prevalence of Human-Immunodeficiency-Virus/Hepatitis-B-virus (HIV/HBV) coinfection and HBV vaccination response in children are unknown in Kwazulu-Natal. This study included 183 HIV-infected and 108 HIV-uninfected children aged between 5 and 15 years screened for HBV infection and vaccination. HBV infection occurred in 2.1% and 0% of HIV-infected and uninfected children respectively. Serological response to immunization was shown in 15.8% and 61.1% of HIV-infected and uninfected children, respectively (P < 0.001). Even if prevalence of HBV infection was low in these cohorts, HIV-infected children will stay at risk of infection if the vaccine schedule is not adapted.
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Beghin, J.-C., Ruelle, J., Sokal, E., Bachy, A., Krishna, M., Hall, L., Goubau, P., & Van der Linden, D. (2017). Effectiveness of the South African expanded program of immunization against hepatitis B in children infected with human immunodeficiency virus-1 living in a resource-limited setting of Kwazulu-Natal. Journal of Medical Virology, 89(1), 182-185. https://doi.org/10.1002/jmv.24598 (Original work published 2017)