t(5;9)(q32;p24) KANK1/PDGFRB

Duhoux, François;Medves, S;Noël, Laura;Ferrant, Augustin;Demoulin, Jean Baptiste;et.al.
(2013) Atlas of Genetics and Cytogenetics in Oncology and Haematology — Vol. 17, n° 2 (2012)

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Abstract
The fusion protein contains the first 741 residues of KANK1 fused to the last 692 residues of PDGFRB (Medves et al., 2010). This includes several coiled-coil domains of KANK1 and the fifth immunoglobulin-like domain, the transmembrane domain and the kinase domain of PDGFRB. The deletion of the immunoglobulin-like domain does not affect the oncogenic activity of the fusion (Medves et al., 2010). By contrast, deletion of the coiled-coil domains prevents cell transformation and signaling via STAT5 and MAP kinases (Medves et al., 2011). Our data suggest that KANK1-PDGFRB adopts a trimeric and multimeric conformation (Medves et al., 2011).
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Duhoux, F., Medves, S., Noël, L., Ferrant, A., Poirel, H., & Demoulin, J. B. (2013). t(5;9)(q32;p24) KANK1/PDGFRB. Atlas of Genetics and Cytogenetics in Oncology and Haematology, 17(2). https://hdl.handle.net/2078.5/90047 (Original work published 2012)