Clinical Characteristics of Leptospirosis in a 7-months Retrospective Hospital-Based Study in Jakarta, Indonesia
(2009) , 24 pages
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- INTRODUCTION Leptospirosis is a widespread zoonosis with protean clinical presentations, ranging from a mild flu-like illness (“anicteric form”) to a fulminant disease, also known as the “Weil’s disease” or “icteric form”, characterized by multiple organ impairment. METHODS: We retrospectively analyzed medical records from 5 major hospitals in Jakarta over a 7 month period and obtained clinical information for 208 confirmed cases (confirmation by IgM-M rapid immunochromatography dipstick assay). RESULTS: Mean age was 39.2 [36.7-41.1] years, with no significant age difference between men and women (p=0.21). The most frequently reported symptoms were fever (86.5%), nausea (77.9%), vomiting (62.5%) and diarrhea (41.35%).The frequency of symptoms was not significantly different across sex and age groups. Overall, our patients presented high leucocytosis (12.5 [CI95% 11.7-13.3]*10³/mm³), thrombocytopenia (91.2 [80.6-103.2]*10³/mm³), elevated creatinin levels (2.5 [2.2- 2.8]mg/dl) and elevated bilirubin levels (2.2 [1.7-2.8] mg/dl). Acute renal failure (ARF) was defined as a creatinin level >1.5mg/dl and was observed in 68.7% of our patients. Nearly 70% of the patients had thrombocytopenia (16 000/mm³) together with elevated creatinin levels (>3mg/dl) and low thrombopenia (platelet count
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le Polain de Waroux, O., Sudaryo, M. K., Louis, V. R., Mahkota, R., Prameswari, M. F., Altare, C., & Guha-Sapir, D. (2009). Clinical Characteristics of Leptospirosis in a 7-months Retrospective Hospital-Based Study in Jakarta, Indonesia (MICRODIS Working Paper Series 2008-July-04). https://hdl.handle.net/2078.5/179480