Ferroportin Q248H mutation, hyperferritinemia and atypical type 2 diabetes mellitus in South Kivu
(2013) Diabetes & Metabolic Syndrome : clinical research & reviews — Vol. 7, n° 2, p. 112-115 (2013)
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- Background: The ferroportin Q248H mutation is relatively common in sub-Saharan Africa. No previous study examined its relationship with atypical diabetes mellitus (DM) in this area. Objective: To determine the potential interactions between ferroportin Q248H mutation, hyperferritinemia and DM in South Kivu (RDC). Methodology: Presence of ferroportin Q248H mutation and iron status were investigated in diabetic patients (n = 179, age (mean) 57.7 years, CRP (median) 0.16 mg/L) and non-diabetic subjects (n = 86, age 44.5 years, CRP 0.07 mg/L) living in the city of Bukavu. Hyperferritinemia was considered for values greater than 200 and 300 μg/L in women and in men, respectively. Results: The prevalence of ferroportin Q248H mutation [12.1%] was non-significantly higher in diabetics than non-diabetics [14.0% vs. 8.1%, p = 0.17]. Similarly, hyperferritinemia frequency was higher in diabetic patients with Q248H mutation [44.0% vs. 14.3%, p = 0.16] and in mutation carriers [37.0% vs 16.5%, p = 0.001] than in the control groups, respectively. The association between Q248H mutation and DM was nevertheless not significant [adjusted OR 1.70 (95% CI: 0.52-5.58), p = 0.37], whereas hyperferritinemia [OR 2.72 (1.24-5.98), p = 0.01] showed an independent effect after adjustment for age and metabolic syndrome. Conclusions: The present work suggests a potential association between abnormal iron metabolism, ferroportin Q248H mutation and atypical DM in Africans, which may be modulated by environmental factors. © 2013 Diabetes India. Published by Elsevier Ltd. All rights reserved.
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Katchunga, P. B., Baguma, M., M’Buyamba-Kabangu, J.-R., Philippé, J., Hermans, M., & Delanghe, J. (2013). Ferroportin Q248H mutation, hyperferritinemia and atypical type 2 diabetes mellitus in South Kivu. Diabetes & Metabolic Syndrome : clinical research & reviews, 7(2), 112-115. https://doi.org/10.1016/j.dsx.2013.02.017 (Original work published 2013)