Effect of an airway clearance technique on nebulized drug delivery in patients with CF: a randomized cross-over trial
(2026) Physiotherapy — p. 101875 (2026)
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EffectofanairwayclearancetechniqueonnebulizeddrugdeliveryinpatientswithCFReychlerg2026.pdf
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- Objectives: The aim of this study was to verify the efficacy of airway clearance technique on drug delivery by nebulization. Design: cross-over study Participants: Stable patients with CF (PwCF) (n=8). Interventions: Participants performed the airway clearance technique before or after the nebulization session. The Autogenic Drainage (AD) was the executed airway clearance techniques. The nebulization session was a delivery of 500mg-amikacin with the AKITA®. Main outcome measures: The primary endpoint was the 24h-urinary excretion of amikacin. Results: PwCF were between 18 and 48 years old (FEV1: 42.9% to 91.5%), all colonized by Pseudomonas aeruginosa, and all with bronchiectasis. Irrespective of the order of the nebulization and the physiotherapy sessions, the total amount of urinary amikacin excretion was similar (Median Difference (95%CI): 0 (-7;4) % of the nominal dose). The elimination constant rate for nebulization before (Median: 0.153 (IQR: 0.071-0.205)) and after the airway clearance technique (0.149 (0.041-0.182); p=0.26) were similar (Median difference (95%CI): 0.02 (-0.004;0.023)). Conclusions: The lung delivery of nebulized medication in PwCF colonized with with Pseudomonas aeruginosa was not improved by the order of the airway clearance and nebulization procedures.
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Reychler, G., Leal, T., Gohy, S., & Aubriot, A.-S. (2026). Effect of an airway clearance technique on nebulized drug delivery in patients with CF: a randomized cross-over trial. Physiotherapy, 101875. https://doi.org/10.1016/j.physio.2026.101875 (Original work published 2026)