Haemophilia is characterised by recurrent bleeding, especially into the joints, which eventually results in chronic crippling arthropathy. Since the early 1960s, replacement therapy using intravenous clotting factors has become available1. Clotting factor concentrates can be administered as on-demand therapy in the event of bleeding episodes, or at regular time intervals, often three times a week, as prophylaxis-therapy to prevent bleeding. (...)
Hermans, C. (2014). Haemophilia Centre certification system across Europe: The Belgian experience. Blood Transfusion, 12(Suppl/ 3), S497-S500. https://doi.org/10.2450/2014.0061-14s (Original work published 2014)