Environmental benefits of switching from intravenous to oral administration of ciprofloxacin

De Jaegher, Nicolas;De Greef, Julien;Briquet, Caroline;Yombi, Jean Cyr;Jeanmart, Hervé;et.al.
(2026) Journal of Antimicrobial Chemotherapy — Vol. 81, n° 6, p. dkag163 [1-2] (2026)

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Abstract
(en) Global warming represents a major threat to human health. The health care sector significantly contributes to this crisis, accounting for ∼4.4% of the global greenhouse gas emissions. Switching readily bioavailable drugs from intravenous (IV) to oral administration has been suggested as a way towards more sustainable practice, although supporting evidence remains scarce. Several antibiotics are suitable for IV to oral switch (IVOS) under appropriate clinical circumstances. IVOS has proven effective in multiple indications, including bacteraemia, osteoarticular infections and endocarditis, and is associated with improved safety, reduced costs and decreased nursing workload. We aimed to assess the environmental impact of IVOS by studying ciprofloxacin, an antibiotic with excellent bioavailability. [...]
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De Jaegher, N., De Greef, J., Briquet, C., Yombi, J. C., Toussaint, Y., Luis Alconero, P., & Jeanmart, H. (2026). Environmental benefits of switching from intravenous to oral administration of ciprofloxacin. Journal of Antimicrobial Chemotherapy, 81(6), dkag163 [1-2]. https://doi.org/10.1093/jac/dkag163 (Original work published 2026)