Influence of sympathetic activation on myocardial contractility measured with ballistocardiography and seismocardiography during sustained end-expiratory apnea.

Morra, Sofia;Gauthey, Anais;Hossein, Amin;Rabineau, Jérémy;van de Borne, Philippe;et.al.
(2020) American journal of physiology. Regulatory, integrative and comparative physiology — Vol. 319, n° 4, p. R497-R506 (2020)

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Authors
  • Morra, Sofia
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  • Gauthey, Anaisorcid-logoUCLouvain
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  • Hossein, Aminorcid-logo
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  • Rabineau, Jérémy
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  • van de Borne, Philippe
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Abstract
Ballistocardiography (BCG) and seismocardiography (SCG) assess vibrations produced by cardiac contraction and blood flow, respectively, through micro-accelerometers and micro-gyroscopes. BCG and SCG kinetic energies (KE) and their temporal integrals (K) during a single heartbeat are computed in linear and rotational dimensions. Our aim was to test the hypothesis that K from BCG and SCG are related to sympathetic activation during maximal voluntary end-expiratory apnea. Multiunit muscle sympathetic nerve traffic [burst frequency (BF), total muscular sympathetic nerve activity (tMSNA)] was measured by microneurography during normal breathing and apnea ( = 28, healthy men). K of BCG and SCG were simultaneously recorded in the linear and rotational dimension, along with oxygen saturation ([Formula: see text]) and systolic blood pressure (SBP). The mean duration of apneas was 25.4 ± 9.4 s. SBP, BF, and tMSNA increased during the apnea compared with baseline ( = 0.01, = 0.002,and = 0.001, respectively), whereas [Formula: see text] decreased ( = 0.02). At the end of the apnea compared with normal breathing, changes in K computed from BCG were related to changes of tMSNA and BF only in the linear dimension ( = 0.85, < 0.0001; and = 0.72, = 0.002, respectively), whereas changes in linear K of SCG were related only to changes of tMSNA ( = 0.62, = 0.01). We conclude that maximal end expiratory apnea increases cardiac kinetic energy computed from BCG and SCG, along with sympathetic activity. The novelty of the present investigation is that linear K of BCG is directly and more strongly related to the rise in sympathetic activity than the SCG, mainly at the end of a sustained apnea, likely because the BCG is more affected by the sympathetic and hemodynamic effects of breathing cessation. BCG and SCG may prove useful to assess sympathetic nerve changes in patients with sleep disturbances. NEW & NOTEWORTHY Ballistocardiography (BCG) and seismocardiography (SCG) assess vibrations produced by cardiac contraction and blood flow, respectively, through micro-accelerometers and micro-gyroscopes. Kinetic energies (KE) and their temporal integrals (K) during a single heartbeat are computed from the BCG and SCG waveforms in a linear and a rotational dimension. When compared with normal breathing, during an end-expiratory voluntary apnea, K increased and was positively related to sympathetic nerve traffic rise assessed by microneurography. Further studies are needed to determine whether BCG and SCG can probe sympathetic nerve changes in patients with sleep disturbances.
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Morra, S., Gauthey, A., Hossein, A., Rabineau, J., Racape, J., Gorlier, D., Migeotte, P.-F., le Polain de Waroux, J. B., & van de Borne, P. (2020). Influence of sympathetic activation on myocardial contractility measured with ballistocardiography and seismocardiography during sustained end-expiratory apnea. American journal of physiology. Regulatory, integrative and comparative physiology, 319(4), R497-R506. https://doi.org/10.1152/ajpregu.00142.2020 (Original work published 2020)