Immune mechanisms in the pathogenesis of cerebral palsy: implication of proinflammatory cytokines and T lymphocytes.

Kadhim, Hazim;Sébire, Guillaume
(2002) European Journal of Paediatric Neurology — Vol. 6, n° 3, p. 139-142 (2002)

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  • Kadhim, HazimUCLouvain
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  • Sébire, GuillaumeUCLouvain
    Author
Abstract
Beyond the already known aetiopathogenic factors linked to periventricular leukomalacia, a major pathological substrate in cerebral palsy, immune-inflammatory mechanisms have recently been implicated. Thus proinflammatory cytokines have been shown to be involved very early in the course of this disorder. Additionally, markers of T-lymphocyte activation were upregulated. These findings provide new insight into mechanisms underlying neural cell death in this condition and might open new horizons for preventive and therapeutic strategies.
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Kadhim, H., & Sébire, G. (2002). Immune mechanisms in the pathogenesis of cerebral palsy: implication of proinflammatory cytokines and T lymphocytes. European Journal of Paediatric Neurology, 6(3), 139-142. https://doi.org/10.1053/ejpn.2002.0581 (Original work published 2002)