The proximal 2-kb of the Hoxa3 promoter directs gene expression in distinct branchial compartments and cranial ganglia
(2004) Developmental Brain Research — Vol. 150, n° 2, p. 211-213 (2004)
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- Developing structures such as hindbrain, neural crest cells or spinal cord express Hoxa3. Here, we have investigated the regulatory role of a 2-kb fragment spanning the proximal promoter of Hoxa3 by a reporter-based approach in mice. We show that this fragment promotes reporter activity in ganglionic and branchial compartments known to express Hoxa3 but for which no cis-regulatory elements have been identified so far. We also show that the 2-kb promoter fragment is active in rhombomere 4 and in the ganglion of the cranial nerve complex VII/VIII that are devoid of Hoxa3 expression.
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Diman, N. Y. S.-G., Chauvier, E., Pacico, N., Picard, J., & Rezsohazy, R. (2004). The proximal 2-kb of the Hoxa3 promoter directs gene expression in distinct branchial compartments and cranial ganglia. Developmental Brain Research, 150(2), 211-213. https://doi.org/10.1016/j.devbrainres.2004.03.013 (Original work published 2004)