La maladie d'Alzheimer: aspects cellulaires et moléculaires.

Octave, Jean-Noël;Pierrot, Nathalie
(2008) Academie Nationale de Medecine. Bulletin — Vol. 192, n° 2, p. 323-331; discussion 331-332 (2008)

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Abstract
(en) [Alzheimer's disease: cellular and molecular aspects] Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.
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Octave, J.-N., & Pierrot, N. (2008). La maladie d’Alzheimer: aspects cellulaires et moléculaires. Academie Nationale de Medecine. Bulletin, 192(2), 323-331; discussion 331-332. https://hdl.handle.net/2078.5/129207 (Original work published 2008)