Experimental Aortic Valve Cusp Extension with CorMatrix in a Porcine Model.

Mosala Nezhad, Zahra;Poncelet, Alain;Fervaille, Caroline;de Kerchove, Laurent;Gianello, Pierre
(2017) The Thoracic and Cardiovascular Surgeon — Vol. 65, n° 3, p. 206-210 (2017)

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Abstract
(en) BACKGROUND : We tested the feasibility of using porcine small intestinal submucosal extracellular matrix (CorMatrix) for aortic valve (AV) repair in porcine model examining its resorption and remodeling potential. METHODS : The non-coronary cusp was replaced with CorMatrix in four animals for 120 days. Valve function was assessed by echocardiography. Explants were examined by histology, immunohistochemistry, and collagen assessment. RESULTS : CorMatrix was almost totally replaced with tissue resembling the native cusp with a partial two-layer architecture. However, function was lost due to thickening and calcification. CONCLUSIONS : Tested in high-pressure AV position in a pig model, CorMatrix degrades and remodels, but also loses function.
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Mosala Nezhad, Z., Poncelet, A., Fervaille, C., de Kerchove, L., & Gianello, P. (2017). Experimental Aortic Valve Cusp Extension with CorMatrix in a Porcine Model. The Thoracic and Cardiovascular Surgeon, 65(3), 206-210. https://doi.org/10.1055/s-0036-1586756 (Original work published 2017)