Interleukin-6 is a pleiotropic cytokine which shows a wide variety of biologic functions on various tissues and cells. Indeed. IL-6 acts not only B cells but also on T cells, hepatocytes, hematopoietic progenitor cells, megakaryocytes, etc. In this review, I have attempted to summarize the new data concerning the effect of IL-6 on megakaryocytes and platelets.
Baatout, S. (1996). Interleukin-6 and megakaryocytopoiesis: an update. Annals of hematology, 73(4), 157-162. https://doi.org/10.1007/s002770050220 (Original work published 1996)