Thyroid hormone stimulates expression of 6-phosphofructo-2-kinase in rat liver.
(1989) FEBS Letters — Vol. 257, n° 2, p. 211-214 (1989)
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- Abstract
- The activity of liver 6-phosphofructo-2-kinase (PFK-2), the enzyme that catalyses the synthesis of fructose 2,6-bisphosphate, was markedly decreased in hypothyroid rats and partially restored after 3 days of treatment with triiodothyronine. The changes in PFK-2 activity were accompanied by parallel changes in enzyme content measured by immunotitration and in PFK-2 mRNA determined by dot blot and Northern blot hybridization with cDNA probes. It is concluded that thyroid hormone stimulates liver PFK-2 gene expression by a pre-translational mechanism.
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Wall, S. R., van den Hove, M. F., Crepin, K. M., Hue, L., & Rousseau, G. (1989). Thyroid hormone stimulates expression of 6-phosphofructo-2-kinase in rat liver. FEBS Letters, 257(2), 211-214. https://doi.org/10.1016/0014-5793(89)81536-4 (Original work published 1989)