The menopausal transition: a 9-year prospective population-based study: The Melbourne Women's Midlife Health Project.

Guthrie, J;Burger, Henry;Lehert, Philippe;Taffe, J;Dennerstein, Lorraine
(2004) Climacteric — Vol. 4 (2004)

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Authors
  • Guthrie, J
    Author
  • Burger, Henry
    Author
  • Lehert, Philippeorcid-logoFUCaM
    Author
  • Taffe, J
    Author
  • Dennerstein, Lorraine
    Author
Abstract
(en) Objectives To determine the hormonal changes relating to the menopausal transition (MT) and how these affect quality of life, bone mineral density, body composition, cardiovascular disease (CVD) risk and memory. Results The late MT coincides with changes in estradiol, follicle stimulating hormone, and free testosterone index, decreases in bone density and mastalgia. Levels of total testosterone and dehydroepiandrosterone sulfate are unchanged by the MT. An increase in CVD risk was associated with increases in weight and free testosterone index and a decrease in estradiol. Depressed mood is increased by symptoms and by stressors occurring in the MT.Menstrual cycles became more variable and longer closer to the final menstrual period. Conclusions As hormonal changes during the MT directly or indirectly adversely affect quality of life, body composition and CVD risk, maintenance of health parameters in the premenopausal years is crucial for a healthy postmenopause.
Affiliations
  • Louvain School of Management

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Guthrie, J., Burger, H., Lehert, P., Taffe, J., & Dennerstein, L. (2004). The menopausal transition: a 9-year prospective population-based study: The Melbourne Women’s Midlife Health Project. Climacteric, 4. https://hdl.handle.net/2078.5/128535 (Original work published 2004)