Beyond congestion : exploring metabolic signatures and potential therapeutic targets in heart failure with preserved ejection Fraction

Menghoum, Nassiba
(2025)

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Authors
  • Menghoum, NassibaUCLouvain
    author
Supervisors
Pouleur, Anne-Catherine
 ;
Beauloye, Christophe
Abstract
Given the complexity of Heart Failure with Preserved Ejection Fraction (HFpEF), a condition with a poor prognosis and limited therapeutic options, this thesis explores two patient cohorts to identify key biomarkers and metabolic drivers. Congestion, a central element in HFpEF, is marked by carbohydrate antigen (CA) 125, a biomarker of severity and hospitalization risk. Beyond congestion, targeted metabolomics reveals plasma myo-inositol as a distinct marker of fibrosis and renal decline, while lipidomic analysis identifies unique HFpEF phenotypes with specific metabolic profiles. Epicardial adipose tissue (EAT) also contributes to HFpEF, positioning EAT as a promising therapeutic target. These findings support the integration of biomarkers and metabolic profiling for more targeted therapeutic approaches.
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Menghoum, N. (2025). Beyond congestion : exploring metabolic signatures and potential therapeutic targets in heart failure with preserved ejection Fraction. https://hdl.handle.net/2078.5/242686