(en) Global urbanization represents a major challenge for developing and emerging countries. Often illustrated for capitals and megalopolis, the less studied development of small and intermediate urban centers also plays an important role in the land use changes within their surrounding rural areas, demonstrated here in the predominant rural context of Cambodia and Vietnam. This thesis characterizes driving forces of rural transformations led by secondary urban centers development in both countries. It focuses on the dynamics of farming and household activity systems from a land use change perspective as well as from a stakeholder perspective. This is carried out by combining different empirical approaches, multiple sources of information and different nested working scales. For the municipality of Sihanoukville on the Cambodian coast, remote sensing and socioeconomic disciplines are combined in an original way to monitor and understand land use dynamics driven by this secondary city. The critical importance of relationships between rural and urban stakeholders is highlighted as well as the influence of the land use planning, the policy and the economical contexts. Local land uses processes are successfully depicted through the specificities and the complementarities of both approaches. The consequences of urban development on the activity system of rural households are then emphasized in the Vietnamese Red River Delta by combining successively remote sensing data and socioeconomic field surveys. Rural activities may change drastically including reconversion or specialization in certain types of agricultural production. The importance of farmers’ initiatives, policy promoting contexts and both close or remote connections to markets places is particularly stressed. Finally, econometric modeling using GIS derived information effectively explains the spatial organization of rural household commercial flows to markets places in Kampong Thom province, Cambodia. It effectively demonstrates the contribution of spatial dimension to socioeconomic dynamics as process explanation. This empirical work explores new methodological designs and contributes to underscore the rich potential of interdisciplinary research.