O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?
(2016) BBA - Molecular Basis of Disease — Vol. 1862, n° 12, p. 2232-2243 (2016)
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- O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAcylation) is a post-translational modification occurring on serine and threonine residues, which is evolving as an important mechanism for the regulation of various cellular processes. The present review will, first, provide a general background on the molecular regulation of protein O-GlcNAcylation and will summarize the role of this post-translational modification in various acute cardiac pathologies including ischemia-reperfusion. Then, we will focus on research studies examining protein O-GlcNAcylation in the context of cardiac hypertrophy. A particular emphasis will be laid on the convergent but also divergent actions of O-GlcNAcylation according to the type of hypertrophy investigated, including physiological, pressure overload-induced and diabetes-linked cardiac hypertrophy. In an attempt to distinguish whether O-GlcNAcylation is detrimental or beneficial, this review will present the different O-GlcNAcylated targets involved in hypertrophy development. We will finally argue on potential interest to target O-GlcNAc processes to treat cardiac hypertrophy. This article is part of a Special Issue entitled: The role of post-translational protein modifications on heart and vascular metabolism edited by Jason R.B. Dyck & Jan F.C. Glatz.
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Mailleux, F., Gélinas, R., Beauloye, C., Horman, S., & Bertrand, L. (2016). O-GlcNAcylation, enemy or ally during cardiac hypertrophy development? BBA - Molecular Basis of Disease, 1862(12), 2232-2243. https://doi.org/10.1016/j.bbadis.2016.08.012 (Original work published 2016)