Determinants of benzo(a)pyrenediol epoxide adducts to haemoglobin in workers exposed to polycyclic aromatic hydrocarbons

Ferreira Júnior, M. F.;Tas, S.;dell'Omo, M.;Goormans, G.;Lauwerys, Robert;et.al.
(1994) Occupational and Environmental Medicine : an international peer-reviewed journal in all aspects of occupational & environmental medicine — Vol. 51, n° 7, p. 451-455 (1994)

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Authors
  • Ferreira Júnior, M. F.
    Author
  • Tas, S.
    Author
  • dell'Omo, M.
    Author
  • Goormans, G.
    Author
  • Buchet, Jean-PierreUCLouvain
    Author
  • Lauwerys, RobertUCLouvain
    Author
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Abstract
OBJECTIVE--The aim was to assess the determinants of benzo(a)pyrenediol epoxide adducts to haemoglobin (BaPDE-Hb) in workers exposed to polycyclic aromatic hydrocarbons (PAHs). METHODS--This was a study of the correlations between the concentrations of PAHs in air, 1-hydroxyprene in urine, and BaPDE-Hb adduct concentration in the blood in 206 men working in steel foundries and one graphite electrode producing plant, taking into consideration confounding factors such as smoking and dietary habits. RESULTS--BaPDE-Hb adduct concentration was correlated (r = 0.26; p = 0.0002) with the airborne PAH concentration and was influenced by tobacco consumption but not by dietary habits. Benzo(a)-pyrene concentration in air, 1-hydroxypyrene concentration in urine, and duration of exposure to PAHs were not associated with the adduct concentration. CONCLUSION--Although environmental exposure to PAHs was statistically associated with BaPDE-Hb adduct concentration, differences between individual subjects in the metabolism of benzo(a)pyrene probably play an important part in determining the amount of BaPDE-Hb adducts formed.
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Ferreira Júnior, M. F., Tas, S., dell’Omo, M., Goormans, G., Buchet, J.-P., & Lauwerys, R. (1994). Determinants of benzo(a)pyrenediol epoxide adducts to haemoglobin in workers exposed to polycyclic aromatic hydrocarbons. Occupational and Environmental Medicine : an international peer-reviewed journal in all aspects of occupational & environmental medicine, 51(7), 451-455. https://doi.org/10.1136/oem.51.7.451 (Original work published 1994)