Microstructural assessment of multiple sclerosis lesions and peri-plaques using advanced multishell diffusion MRI

Vanden Bulcke, Colin;Stölting, Anna;Absinta, Martina;Maggi, Pietro
(2023) European Committee for Treatment and Research in Multiple Sclerosis — Location: Milan (11.October.2023)

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Authors
  • Vanden Bulcke, Colinorcid-logoUCLouvain
    Author
  • Stölting, Annaorcid-logoUCLouvain
    Author
  • Absinta, MartinaInstitute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Hospital and Vita-Salute San Raffaele University, Milan, Italy
    Author
  • Maggi, PietroUCLouvain
    Author
Abstract
Chronic active multiple sclerosis (MS) lesions, seen on susceptibility-based MRI as Paramagnetic Rim Lesions (PRL), are associated with increased clinical disability and axonal damage. Diffusion MRI (dMRI) can characterize in vivo tissue damage, however, the tissue microstructure specificity of established dMRI models is limited. Here, we characterized PRL vs non-PRL microstructure and their surrounding peri-plaque white matter (PPWM) using Track Density Imaging (TDI) and 4 different dMRI models, including two novel ones; Microstructure Fingerprinting (MF) and DIstribution of Anisotropic MicrOstructural eNvironments in DWI (DIAMOND). To our knowledge, MF, DIAMOND, and TDI have never been used to depict the microstructure of MS lesions. Consistent with previous data, we show that PRL and their surrounding PPWM are characterized by higher axonal damage when compared to non-PRL. Results derived from the TDI, MF and DIAMOND models are in line with those obtained with DTI and NODDI, suggesting that these advanced diffusion imaging methods can be used to study MS lesion pathology.
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Vanden Bulcke, C., Stölting, A., Absinta, M., & Maggi, P. (2023). Microstructural assessment of multiple sclerosis lesions and peri-plaques using advanced multishell diffusion MRI. Multiple Sclerosis Journal, Volume 29(Issue 3_suppl), 394-649. https://doi.org/10.1177/13524585231196194 (Original work published 2023)