In a case of pediatric Whipple disease confined to the central nervous system, white matter lesions initially appeared as areas of very low signal intensity on T1-weighted MR images and as areas of hyperintensity on proton density-weighted and T2-weighted images, and showed slight peripheral enhancement on delayed contrast-enhanced T1-weighted images. On MR studies obtained 3 and 6 months after antibiotic therapy, the lesions had decreased in size and no longer enhanced. They became progressively less hypointense on T1-weighted images and less hyperintense on T2-weighted images.
Duprez, T., Grandin, C., Bonnier, C., Thauvoy, C., Gadisseux, J. F., Dutrieux, J. L., & Evrard, P. (1996). Whipple disease confined to the central nervous system in childhood. American Journal of Neuroradiology, 17(8), 1589-1591. https://hdl.handle.net/2078.5/135426 (Original work published 1996)