(en) In this issue of the Journal, Sardar et al. (1) report the results of a meta-analysis evaluating the blood pressure (BP) response to renal sympathetic denervation (RSD) in 6 sham-controlled randomized clinical trials including 3 recently published trials and totaling 977 patients. Compared with sham control, RSD significantly reduced both systolic and diastolic office, 24-h ambulatory, and daytime BP. The authors conclude that these results should guide the design of larger, pivotal trials to evaluate the long-term efficacy and safety of RSD in patients with uncontrolled and resistant hypertension. [...]
Kjeldsen, S. E., Fadl Elmula, F. E. M., & Persu, A. (2019). Future of Renal Sympathetic Denervation in the Treatment of Hypertension. Journal of the american college of cardiology : JACC, 73(13), 1643-1645. https://doi.org/10.1016/j.jacc.2019.02.008 (Original work published 2019)