Expression and GTP sensitivity of peptide histidine isoleucine high-affinity-binding sites in rat. : EXPRESSION AND GTP SENSITIVITY IN RAT
(2006) Annals of the New York Academy of Sciences — Vol. 1070, p. 215-219 (2006)
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- Abstract
- High-affinity-binding sites for the vasoactive intestinal peptide (VIP) analogs peptide histidine/isoleucine-amide (PHI)/carboxyterminal methionine instead of isoleucine (PHM) are expressed in numerous tissues in the body but the nature of their receptors remains to be elucidated. The data presented indicate that PHI discriminated a high-affinity guanosine 5'-triphosphate (GTP)-insensitive-binding subtype that represented the totality of the PHI-binding sites in newborn rat tissues but was differentially expressed in adult animals. The GTP-insensitive PHI/PHM-binding sites were also observed in CHO cells over expressing the VPAC2 but not the VPAC1 VIP receptor.
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Debaigt, C., Meunier, A.-C., Goursaud, S., Montoni, A., Pineau, N., Couvineau, A., Laburthe, M., Muller, J.-M., & Janet, T. (2006). Expression and GTP sensitivity of peptide histidine isoleucine high-affinity-binding sites in rat. : EXPRESSION AND GTP SENSITIVITY IN RAT. Annals of the New York Academy of Sciences, 1070, 215-219. https://doi.org/10.1196/annals.1317.017 (Original work published 2006)