SM and MPF levels were more closely associated with disease course than OPN and might prove useful in monitoring patient response in mesothelioma. Baseline OPN levels were an independent negative predictor of survival. These promising results require further validation.
Hollevoet, K., Nackaerts, K., Gosselin, R., De Wever, W., Bosquée, L., De Vuyst, P., Germonpré, P., Kellen, E., Legrand, C., Kishi, Y., Delanghe, J. R., & van Meerbeeck, J. P. (2011). Soluble mesothelin, megakaryocyte potentiating factor, and osteopontin as markers of patient response and outcome in mesothelioma. Journal of Thoracic Oncology, 6(11), 1930-1937. https://doi.org/10.1097/JTO.0b013e3182272294 (Original work published 2011)