DNA methylation-based classification uncovers acinar and ductal origins for KPC-derived PDAC cell lines

Zoi, Ilianna;Rajput Bhatti, Memoona;Holguín-Horcajo, Adrián;Haidar, Malak;Jacquemin, Patrick;et.al.
(2026) Cancer Letters — Vol. 656, p. 218666 [1-4] (2026)

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Abstract
(en) Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by significant inter- and intra-tumoral heterogeneity. The KPC (Pdx1Cre; KrasLSL−G12D;p53LSL−R172H) mice has become the standard model for studying human PDAC, as it faithfully recapitulates its histological and molecular features, including its pronounced tumor heterogeneity. In this model, oncogenic Kras and mutant p53 are expressed during embryogenesis in multipotent pancreatic progenitors that will give rise to both differentiated acinar and ductal cells, after birth (note that the promoter of the Ptf1a gene can also be used to drive Cre expression with a comparable result). [...]
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Zoi, I., Rajput Bhatti, M., Holguín-Horcajo, A., Haidar, M., Brusa, D., Chu, K., Xie, J., Shields, M., Ferreira, S. M., Stanger, B., Attardi, L. D., Kopp, J., Stemmler, M. P., Nicolle, R., Rovira, M., & Jacquemin, P. (2026). DNA methylation-based classification uncovers acinar and ductal origins for KPC-derived PDAC cell lines. Cancer Letters, 656, 218666 [1-4]. https://doi.org/10.1016/j.canlet.2026.218666 (Original work published 2026)