Beta-arrestin 2 is absolutely required for the potentiation of insulin secretion by GIP
(2020) 56th EASD Annual Meeting of the European Association for the Study of Diabetes — Location: (Austria) Vienna (21.September.2020)
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- Background and aims: The scaffold protein beta-arrestin2 (ARRB2) is known to uncouple G protein coupled receptors (GPCRs) from the G protein and to recruit new signaling pathways (such as the ERK1/2, PI3K, FAK⋯). In non beta cells, ARRB2 interacts with a wide range of GPCRs, but its interaction with the GIP receptor (GIPR) is still unclear. Our aim is to determine if ARRB2 is involved in the signaling of the GIPR in pancreatic beta cells. [...]
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Citations
Ravier, M. A., Obeid, J., Leduc, M., Costes, S., Gilon, P., Dalle, S., & Bertrand, G. (2020). Beta-arrestin 2 is absolutely required for the potentiation of insulin secretion by GIP. Diabetologia : clinical and experimental diabetes and metabolism, 63(Suppl 1), S252. https://hdl.handle.net/2078.5/249063 (Original work published 2020)