Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model.

Ohtomo, Shuichi;Izuhara, Yuko;Nangaku, Masaomi;Dan, Takashi;Miyata, Toshio;et.al.
(2010) International Journal of Obesity — Vol. 2010, n° Epub 2010 Feb 17, p. Epub 2010 Feb 17 (2010)

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OhtomoSetalBodyweightcontrolbyahig-carbohydratelow-fatdietslowstheprogressionofdiabetickidneydamageinanobesehypertensivetype2diabeticratmodelJObes2010.pdf
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Authors
  • Ohtomo, Shuichi
    Author
  • Izuhara, Yuko
    Author
  • Nangaku, Masaomi
    Author
  • Dan, Takashi
    Author
  • Van Ypersele de Strihou, CharlesUCLouvain
    Author
  • Miyata, Toshio
    Author
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Abstract
Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN). Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group). Daily caloric intake was the same in both groups. Nevertheless, the HC/LF group gained less weight. Despite equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had less severe renal histological abnormalities and a reduced intrarenal advanced glycation and oxidative stress. Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin. Altogether, these data identify a specific role of body weight control by a high-carbohydrate/low-fat diet in the progression of DN. Body weight control thus impacts on local intrarenal advanced glycation and oxidative stress through inflammation and adiponectin levels.
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Ohtomo, S., Izuhara, Y., Nangaku, M., Dan, T., Ito, S., Van Ypersele de Strihou, C., & Miyata, T. (2010). Body weight control by a high-carbohydrate/low-fat diet slows the progression of diabetic kidney damage in an obese, hypertensive, type 2 diabetic rat model. International Journal of Obesity, 2010(Epub 2010 Feb 17), Epub 2010 Feb 17. https://doi.org/10.1155/2010/136502 (Original work published 2010)